Human Sera
Cayman Chemical 2MethylamIno1phenylbutn 50mg
A methamphetamine analog with structural similarity to 2-ethylamino-1-phenylbutane; intended for forensic and research applications
Cayman Chemical SID 3712249 50mg
An inhibitor of miR-544 biogenesis; increases MTOR mRNA expression and decreases the mRNA expression of the genes encoding miR-544, HIF-1α, and ATM in MDA-MB-231, MCF-7, and MCF-10A cells under hypoxic conditions at 20 nM; induces apoptosis in MDA-MB-231 cells in a hypoxia- and mTOR-dependent manner at 20 nM; enhances the senstivity of MCF-7 and MDA-MB-231 cells cultured under hypoxic conditions to 5-FU-induced decreases in cell viability at 20 nM; reduces tumor growth in an MDA-MB-231 mouse xenograft model
Cayman Chemical PalIfosfamIde 50mg
An active metabolite of ifosfamide; formed through hydroxylation of ifosfamide by various hepatic CYP isoforms; cytotoxic to L1210 and CCRF-CEM cancer cells at 100 µM; reduces tumor growth in Lewis lung carcinoma and L1210 leukemia mouse models, as well as a rat Yoshida ascitic sarcoma model at 100 mg/kg per da
Cayman Chemical R-CetIrIzInhydrochlorIde 50mg
A selective histamine H1 receptor antagonist; the (R)-enantiomer of cetirizine; binds to the H1 receptor with higher affinity than cetirizine (Kis = 3 and 6 nM, respectively) and is highly selective for H1 over M1-M5 receptors; decreases production of RANTES and eotaxin following antigen stimulation in mouse eosinophils in vitro (MEC = 0.05 µM); dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice (0.01-1% solution)
Cayman Chemical DIhomoLInolenIc ACD ethyl 50mg
An ester form of DGLA; dietary administration of ethyl DGLA at 1 g/kg per day increases PGE1 and PGE2 secretion in rabbit renal papilla; increases triglyceride levels and the proportion of 20:3ω6 and 20:4ω6 phospholipids of the renal medulla in rabbits
Cayman Chemical Lnnamvr 50mg
An inhibitor of influenza neuraminidases and an active metabolite of laninamivir octanoate; inhibits the neuraminidases from influenza A H1N1, H2N2, and H3N2 strains (mean IC50s = 2.49, 11.4, and 16.7 nM, respectively) and influenza B Victoria and Yamagata strains (mean IC50s = 18.9 nM for both); increases survival in a mouse model of lethal influenza H1N1 infection when administered intranasally at 69 UG/kg
Cayman Chemical PhentolamInmesylate 100mg
A reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities; rapidly and transiently increases local blood flow
Cayman Chemical 3mthylaPyrroldInobutIoph 50mg
An isomer of 4-methyl-α-PBP, having the methyl group attached at the 3 position of the phenyl ring, instead of the 4 position; intended for forensic and research applications
Cayman Chemical 5bromo3IndolylDGalacto 100mg
A chromogenic substrate for β-galactosidase; upon enzymatic hydrolysis, it generates an indigo-colored precipitate that can be used to measure β-galactosidase activity; has been used to detect β-galactosidase in muscle from E. coli lacZ-expressing transgenic mice
Cayman Chemical BretylIumtosylate 50mg
A class III antiarrhythmic agent; has antiadrenergic activity in isolated tissue preparations; an inhibitor of the Na+/K+-ATPase (IC50 = 4.5 mM); prevents ventricular fibrillation in anesthetized dogs in a model of sudden coronary death at 10 mg/kg; inhibits NCTs, as well as increases action potential delay and the absolute refractory period in isolated mouse vas deferens sympathetic nerve terminals
Cayman Chemical TofacItInIbcItrate 50mg
A JAX inhibitor (IC50s = 6.1, 12, and 8 nM for JAK1, JAK2, and JAK3, respectively); selective for JAK1-3 over ROCK2 and Lck (IC50s = 3,400 and 3,870 nM, respectively) as well as 28 additional kinases in enzyme assays (IC50s = >10,000 nM); inhibits IL-2-mediated phosphorylation of JAK3 and STAT5 (30 ng/ml); prevents rejection and prolongs survival in murine and cynomolgus monkey models of heterotopic heart and kidney transplantation
Cayman Chemical 4Hydroyphenylglyoylc ACD 50mg
A CPT1 inhibitor and an active metabolite of oxfenicine; inhibits CPT1 in isolated rat liver mitochondria from 200 to 1,000 µM; inhibits oleate oxidation in isolated rat hepatocytes
Cayman Chemical CarbIdopahydrate 50mg
A dopamine decarboxylase inhibitor; inhibits conversion of L-DOPA to dopamine in the periphery; increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66% in dog when administered at a dose of 100 mg/kg; potentiates the activity of AhR; inhibits proliferation of pancreatic cancer cells in vitro and tumor growth in vivo