Human Sera
Cayman Chemical GunosIn 5trIphosphATso 100mg
An active metabolite of valganciclovir and an antiviral nucleoside derivative reduces human monkey mouse and guinea pig CMV replication in plaque reduction assays (EC50s 1.3-70 UM) topical application decreases disease severity and corneal leukocyte infiltration in a cat model of ocular FHV-1 epithelial infection at 0.15 prevents allograft histologic injury and NK and myeloid cell infiltration in a mouse model of murine CMV infection with renal transplantation at 15 mg/kg induces tumor regression in a K-BALB murine sarcoma model using a mixed population of HSV TK positive or negative cells
Cayman Chemical IvabradInhydrochlorIde 50mg
A major urinary metabolite of PGD2 with a unique lower sidechain that readily undergoes reversible cyclization used as a biomarker to assess endogenous production of PGD2
Cayman Chemical DobutamInhydrochlorIde 50mg
An OEA analog that stimulates PPARa transcriptional activity (EC50 100 nM) and prolongs feeding latency in rodents (ED50 2.4 mg/kg) as potent as OEA yet resistant to enzymatic hydrolysis demonstrates weak affinity for the CB1 and CB2 receptors (Ki 33 and 26 UM respectively
Cayman Chemical ProstaglndIn F2a 50mg
A minor bioactive component of ginger with anti-inflammatory and anticancer properties induces apoptosis in cancer cells through the production of reactive oxygen species and the activation of caspase impairs tubulin polymerization downregulates NF-KB signaling inhibits the expression of inflammatory mediators suppresses Toll-like receptor signaling and enhances antioxidant defense mechanisms by inducing Nrf2/ARE-mediated gene expression
Cayman Chemical MonbromobImn 100mg
A lipophilic electrophile that has profound effects on oxidative and immunological pathways activates the transcription factor Nrf2 resulting in heme oxygenase-1 expression and increased glutathione levels suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis
Cayman Chemical ClInafloxacInhydroCLOrID 100mg
A tetrachloro indandione that acts as a potent inhibitor of UCH-L3 and demonstrates 125-fold selectivity over UCH-L1 (IC50s 0.6 and 75 UM respectively)
Cayman Chemical FexofenadInhydrochlorIde 100mg
An irreversible inhibitor of mutant forms of EGFR including T790M (Ki 21.5 nM) with minimal activity at the wild-type EGFR (Ki 303.3 nM) inhibits the proliferation of NSCLC cells expressing mutant EGFR (GI50s 7-32 nM) and demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft and transgenic models
Cayman Chemical 2-AmInopurInhydrochlorIde 50mg
An orally active Ras inhibitor with selectivity for H-Ras (Ki 46 M) inhibits both anchorage-dependent and -independent growth and induces apoptosis of H-RasG12V-transformed NIH 3T3 cells (IC50 ~1.5 M) exhibits antitumor activity in mice bearing a xenograft of human colon cancer SW480 cells expressing K-RasG12V at an oral dose of 80 mg/kg
Cayman Chemical SolIfenacInsuccInate 50mg
A tricyclic antidepressant binds to NET (Kd 11 nM) selective for NET over the serotonin and dopamine transporters (Kds 5800 and 1000 nM respectively) binds to 5-HT2A (Ki 51 nM) as well as histamine H1 muscarinic acetylcholine a1-adrenergic and dopamine D2 receptors (Kds 2 570 90 and 350 nM respectively) inhibits norepinephrine reuptake in rat brain and peripheral tissues reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice from 3-10 mg/kg prevents acid sphingomyelinase activation and subsequent ceramide release induced by pp-VSV-SARS-CoV-2 infection in Vero cells at 20 UM
Cayman Chemical MefloquInhydrochlorIde 100mg
A spin trap used in the study of oxidative DNA damage and nitroso-compound-induced respiratory burst in neutrophils
Cayman Chemical BenIdIpInhydrochlorIde 100mg
A metabolite of pregnenolone that modulates NMDA receptor responses to exogenously applied glutamate and stimulates TRPM3
Cayman Chemical AmIprofos-methyl 50mg
An atypical antipsychotic a partial agonist at dopamine D2 D2L and D3 receptors (Kis 3 3 0 74 9 7 nM respectively) a partial agonist of 5-HT1A receptors (Ki 5 6 nM) and an inverse agonist of 5-HT2B receptors (Ki 0 36 nM) inhibits disruptions in prepulse inhibition induced by phencyclidine in mice when administered at doses of 5 and 10 mg/kg
Cayman Chemical CarbetocInacetate 50mg
A prodrug form of GS-443902 reduces viral titers in primary HAE cells infected with MERS-CoV or SARS-CoV (EC50s 0.074 and 0.069 UM respectively) reduces infectious virus production in SARS-CoV-2-infected HAE cells (EC50 10 nM) reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection at 25 and 50 mg/kg reduces lung viral titer and lung hemorrhage and improves pulmonary function in mice infected with a chimeric SARS-CoV encoding the SARS-CoV-2 RdRp at 25 mg/kg
Cayman Chemical TuftsInhumntrIfluoroace 100mg
A C-glycosylated flavone scavenges DPPH radicals in a cell-free assay (IC50 370 Ug/ml) cytotoxic to HepG2 MCF-7 and HCT116 cancer cells at 50 and 100 Ug/ml inhibits LPS-induced production of TNF-a and IL-6 and decreases iNOS and COX-2 levels in RAW 264.7 cells at 50 Ug/ml reduces cytotoxicity induced by AB (25-35) in PC12 cells at 200 Ug/ml
Cayman Chemical 2Methyl2thIazolIn4carbo 50mg
A polyphenolic glycoside flavone with diverse biological activities scavenges DPPH radicals (IC50 6.44 g/ml) active against S. aureus P. aeruginosa S. typhi C. albicans C. parapsilosis and C. neoformans (MICs 8 16 2 16 4 and 4 g/ml respectively) inhibits the proliferation of A549 SKOV3 and SK-MEL-2 cells (EC50s 40.6 34.5 and 33.9 g/ml respectively) reduces the number of eosinophils other inflammatory cells and total cells as well as the levels of IL-4 IL-5 and IL-13 in BALF in a mouse model of allergic asthma at 26 mg/kg per day